Immunohistochemistry Catalog
Entries with Names starting with 'D'
Desmin
Clone: E18-V
Cat#: DB 148
Desmin is an intermediate filament protein of both smooth and striated muscles. E18-reacts with striated (skeletal V and cardiac) as well as smooth muscle cells. In skeletal and cardiac muscles, the staining is confined to the Z-bands giving a characteristic striated appearance. Useful in indication of tumors of myogenic origin. It reacts with leimyosarcomas, as well as, rhadbomyosarcomas (striated muscle).
Fixed-embedded human uterus leiomyoma
DOG1
Clone: DOG1.1
Cat#: 10119
DOG1 is expressed ubiquitously in gastrointestinal stromal tumors (GIST) irrespective of kit or PDGFR alpha mutation status. Reactivity for DOG1 may aid in the diagnosis of GISTs, including PDGFRA mutants that fail to express KIT antigen, and lead to appropriate treatment with imatinib mesylate, an inhibitor of the KIT tyrosine kinase.