Immunohistochemistry Catalog
Entries with Names starting with 'C'
c-erbB-2/HER2/neu
Clone: SP3
Cat#: 10047
This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c erbB family. It is closely related in structure to the epidermal growth factor receptor. C-erbB- 2 oncoprotein is detectable in a proportion of breast and other adenocarcinomas, as well as transitional cell carcinomas.
Fixed-embedded human breast cancer
C3d complement
Clone: E28-P
Cat#: 10095
C3d is involved in the regulation of many aspects of the immune response including antigen processing and presentation. The C3d/antigen complex mediates B cell activation.
Fixed-embedded human Pemphygus vulgaris
C4d complement
Clone: A24-T
Cat#: 10096
Activation of the classical complement pathway starts with binding of an activating substance to the Cl molecule, which activates the Cl sub-units, resulting in cleavage of C4 to C4b releasing C4a in the process. The short-lived C4b molecule can bind covalently to membranes. This process is limited to the immediate vicinity of the Cl complex. Because of the short life of the C4b molecule much of the C4d is free and circulates in serum.
Fixed-embedded human lymph node
CD10
Clone: G27-P
Cat#: DB 057
Common acute lymphoblastic leukemia antigen (CALLA / CDlO) immunostaining is a useful marker for the characterization of childhood leukemia and B cell lymphomas. This antibody reacts with antigen of lymphoblastic, Burkitt's, and follicular lymphomas; and chronic myelocytic leukemia. Other non-lymphoid cells that are reactive with CDlO are breast myoepithelial cells, bile canaliculi, neutrophils and small population of bone marrow cells, fetal small intestine epithelium, and normal fibroblasts.
Fixed-embedded human tonsil
CD117 (c-kit)
Clone: PC
Cat#: 10086
This antibody reacts with a 145 kDa molecular weight protein, designated as CD117/c-kit. C-kits are transmembrane receptor tyrosine kinases expressed in many tissues and cells and are involved in the development of severa l lineages of stem cells such as germ cells, neuronal crest derived melanocytes and hematopoietic precursor cells. Useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, and tumors of smooth muscle origin.
Fixed-embedded human naevus
CD15
Clone: E26-A
Cat#: DB 211
CD15 is a myelomonocytic antigen expressed by more than 95% of mature peripheral blood eosinophils and neutrophils and is present at
low density on circulating monocytes. In lymphoid tissue, CD15 reacts with Reed-Sternberg cells of Hodgkin's disease and with
granulocytes. However, CD15 reacts with few tissue macrophages and does not react with dendritic cells.
Fixed-embedded human Hodgkin's-lymphoma
CD163
Clone: K20-T
Cat#: DB 045
CD163 is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal
centres of lymphoid follicles, interdigitating reticulum cells and Langerhans cells. In addition, multi-nucleated cells within inflammatory lesions are reported not to express CD163 protein. It has been proposed
that a specific release mechanism of soluble CD163 antigen by human monocytes may play an important role in inflammatory processes.
Fixed-embedded human placenta
CD1a
Clone: L21-A
Cat#: DB 071
Langerhans cells, interdigitating dendritic cells and medullary thymocytes are labelled with this antibody.
Fixed-embedded human skin
CD20
Clone: E17-P
Cat#: DB 041
The CD20 antigen is expressed on normal and malignant human B cells and is thought to act as a receptor during B cell activation and
differentiation. This antibody intensely stains germinal center cells and B immunoblasts in lymphoid tissues.
Fixed-embedded human tonsil
CD205
Clone: R18-D
Cat#: 10090
CD205 (DEC-205) a C-type lectin of family of macrophage mannose receptors (MMR) is strongly expressed by myeloid dendritic cells and monocytes; weaker by B cells and very low by NK, plasmatoid DC, T cells, cortical epithelial cells. Immunohistochemical staining of C0205 in tissue sections allows the quantitative detection of antigen-presenting cells.
Fixed-embedded human colon cancer
CD21
Clone: Q22-S
Cat#: 10099
CD21 (CR2, EBV-receptor) is present on mature B cells and follicular dendritic cells (FDCs). This antibody can be used to demonstrate the FDC network in lymphoid tissue. This feature can be useful in examining tissue with germinal centre lesions resulted by disease processes, such as HIV infection, some neoplastic conditions, like 8-cell MALT lymphomas, mantle cell lymphoma, and some T cell lymphomas.
Fixed-embedded human Castleman lymphoma
CD23
Clone: E28-S
Cat#: DB 135
CD23 is strongly expressed on EBV transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell CLL and some cases of centroblastic/centrocytic lymphoma.
Fixed-embedded human lymph node
CD3
Clone: N26-R
Cat#: 10088
CD3 (also known as T3 complex) is a multimeric protein complex composed of four polypeptide chains funct ioning as three pairs of dimers.It is a T cell co-receptor binding to the T cell receptor (TCR). Both TCR s and CD3 are specific features of cel l s belonging to the T cell lineage.
Fixed-embedded human colon cancer
CD31
Clone: JC-70
Cat#: 10107
The antibody strongly labels endothelial cells and is valuable for the demonstration of capillaries and neoplasms arising from endothelial cells.
Fixed-embedded human tissue
