Immunohistochemistry Catalog
Entries with Names starting with 'M'
Melan A (MART1)
Clone: M2-9E3
Cat#: 10133
Melan A is a melanocyte differentiation antigen. It is present in melanocytes of normal skin and retina, nevi and in more than 85% of melanomas. Very useful in establishing the diagnosis of metastatic melanomas.
Fixed-embedded human melanoma
Melanosome (gp100)
Clone: P14-V
Cat#: DB 049
Expression of gp100 antigen is characteristic of junctional activity and malignant melanoma. This antibody is useful for assessment of malignant melanoma, metastatic amelanotic melanoma.
Fixed-embedded human melanoma
mGluR1
Clone: 3/G11
Cat#: 10033
3/G11 reacts on mGluR protein, which is present in brain, heart, kidneys and also in melanomas from mutant mouse melanocytes. Two types of glutamate receptors exist: ionotropic, and metabotropic receptors. Metabotropic receptors are G-protein coupled receptors, which can activate phospholipases or adenylyf -cyclases, depending on the neuron.
Fixed-embedded rat brain
MLH1
Clone: G168-728
Cat#: 10070
MLH1 is a mismatch repair gene that is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MLH1 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Fixed-embedded human colon cancer
MSH2
Clone: 25D12
Cat#: 10071
MSH2 protein is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis.
Fixed-embedded human colon cancer
Myogenin
Clone: F5D
Cat#: 10134
Myogenin is a nuclear antigen of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilm's tumor. Negative in Ewing sarcomas.