Immunohistochemistry Catalog
Rabbit Monoclonal Anti-
bcl-2
Clone: P21-A
Cat#: DB 064
Bcl-2 is important protein during the process of apoptosis. The antibody may be useful in the classification of follicular lymphomas and various diffuse lymphoproliferative diseases, and for differential identification of diffuse large B-cell lymphoma versus Burkitt lymphoma/leukemia.
Fixed-embedded human tonsil
c-erbB-2/HER2/neu
Clone: SP3
Cat#: 10047
This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c erbB family. It is closely related in structure to the epidermal growth factor receptor. C-erbB- 2 oncoprotein is detectable in a proportion of breast and other adenocarcinomas, as well as transitional cell carcinomas.
Fixed-embedded human breast cancer
CD117 (c-kit)
Clone: PC
Cat#: 10086
This antibody reacts with a 145 kDa molecular weight protein, designated as CD117/c-kit. C-kits are transmembrane receptor tyrosine kinases expressed in many tissues and cells and are involved in the development of severa l lineages of stem cells such as germ cells, neuronal crest derived melanocytes and hematopoietic precursor cells. Useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, and tumors of smooth muscle origin.
Fixed-embedded human naevus
COX-2
Clone: SP21
Cat#: 10075
COX-2 inhibition by nonsteroidal anti inflammatory agents has been shown to decrease angiogenesis and tumor grovvth, and promote apoptosis. COX-2 overexpression has been associated with increased microvascular density, and V EGF protein expression in head and neck squamous cell carcinoma and is an indicator of poor prognosis.
Fixed-embedded human colon cancer
Cyclin D1
Clone: SP4
Cat#: 10074
Immunodetection of Cyclin Dl is useful for separating mantle cell lymphomas (+) from SLL's and small cleaved cell lymphomas (-). Cyclin D , one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of neoplasms. Cyclins govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin dependent kinases. ln mid to late Gl, Cyclin Dl shows maximum expression following growth factor stimulation.
Fixed-embedded human mantle cell lymphoma
Ki-67
Clone: SP6
Cat#: 10080
Ki-67 is expressed in the proliferating cells preferentially during late G1-, S-, M-, and G2- phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
Fixed-embedded human lymph node
Podoplanin
Clone: D2-40
Cat#: 10081
D2-40 is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi's sarcomas and in a subset of angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas, hemangioblastomas and seminomas.
Fixed-embedded human tonsil