Immunohistochemistry Catalog
Rabbit Clonal Anti-
Kappa light chain
Clone: A21-Y
Cat#: 10091
Kappa light chains are polypeptide chains located in cell membrane and cytoplasmic regions of normal B cells and plasma cells. This antibody is reportedly useful in identification of leukemias, plasmacytomas, and other B-cell non- Hodgkin's lymphomas.
Fixed-embedded human tonsil
Melanosome (gp100)
Clone: P14-V
Cat#: DB 049
Expression of gp100 antigen is characteristic of junctional activity and malignant melanoma. This antibody is useful for assessment of malignant melanoma, metastatic amelanotic melanoma.
Fixed-embedded human melanoma
p16
Clone: R19-D
Cat#: DB 152
P16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore acts as a tumor suppressor. Hypermethylation, mutation, or deletion of p16 leads to downregulation of the gene and can lead to cancer through the dysregulation of cell cycle progression. Double staining with Ki-67 can provide insight into cell cycle status.
Fixed-embedded human cervix cancer
p63
Clone: I27-I
Cat#: DB 134
P63 is a 63 kDa protein. The p63 gene is highly expressed in the basal or progenitor layers of many epithelial tissues. P63 shows remarkable structural similarity to p53 gene. Unlike p53, the p63 gene encodes multiple isotypes with divergent abilities to transactivate p53 reporter genes and induce apoptosis.
Fixed-embedded human prostate
PLAP (Placental alkaline phosphatase)
Clone: P16-D
Cat#: DB 047
P16-D is useful in the identification of testicular germ cell tumors. The antibody shows no cross-reaction with other isoenzymes of alkaline phosphatases.
Fixed-embedded human seminoma
Progesterone receptor (PgR)
Clone: X22-C
Cat#: DB 108
PgR is an estrogen-regulated protein. It has been proposed that expression of PgR indicates a responsive ER pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response
to endocrine therapy and estimating survival.
S-100 protein
Clone: D28-E
Cat#: DB 055
Antibody to S100 stains schwannomas, ependymomas, astrogliomas, nevi and almost all malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.
Fixed-embedded human neurofibroma
Synaptophysin
Clone: Q21-Q
Cat#: 10098
Synaptophysin is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms. Synaptophysin contains four trans-membrane domains that form a hexameric channel or gap junction-like pore.
Fixed-embedded human vegetative ganglion
Thyroid Transcription Factor (TTF-1)
Clone: G21-G
Cat#: DB 089
TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas from the breast, mediastinal germ cell tumors and malignant mesothelioma. It can also be used to differentiate Small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non -small cell lung carcinoma has been associated with aggressive behavior of such neoplasms.
Fixed-embedded human thyroid