Immunohistochemistry Catalog
Entries with Names starting with 'E'
E-Cadherin
Clone: ECH-6
Cat#: 10072
E-Cadherin is a calcium dependent cell adhesion molecule, expressed predominantly in epithelial tissues. E-Cadherin has important role in growth and development of cells via the mechanisms of control of tissue architecture and maintenance of tissue integrity. Reduction and/or loss of E-Cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
Fixed-embedded human skin
EBV/LMP
Clone: D24-G
Cat#: 10093
Epstein-Barr virus (EBV) is a virus of the herpes family (HHV-4), and is one of the most common viruses in humans. EBV is associated with a high proportion of cases of Hodgkin's disease, expression has also been found in nasopharyngeal carcinoma and non-lymphoblastic T-cell lymphomas.
Fixed-embedded human Hodgkin lymphoma
EGFR
Clone: A20-E
Cat#: DB 092
Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kDa with tyrosine kinase activity. Increased level of EGFR is correlated with malignant transformation of squamous cells e.g. in squamous cell carcinoma of lung, head and neck, skin, cervix and oesophagus.
Fixed-embedded human placenta
EMA (CD227, Mucin-1)
Clone: G22-L
Cat#: DB 048
EMA is expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also positive on activated and unactivated T cells and plasma cells. Over-expressed in epithelial tumors, such as breast or ovarian cancer and also in non epithelial tumor cells.
Fixed-embedded human lung adenocarcinoma
EpCAM
Clone: MOC-31
Cat#: 10129
This antibody reacts with a transmembrane glycoprotein present on most normal and malignant epithelia. Mesothelial cell derived tumors are negative.
Fixed-embedded tissue
ER (Estrogen receptor)
Clone: S21-V
Cat#: DB 053
This antibody recognizes a protein of 67 kDa, which is identified as estrogen receptor (ER) and stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast cancers indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Fixed-embedded human breast cancer