Immunohistochemistry Catalog
Rabbit Clonal Anti-
CD7
Clone: C21-Q
Cat#: DB 114
CD7 antigen is a cell surface glycoprotein expressed on the surface of immature and mature T cells, and natural killer cells. While its precise function is not known, there is recent suggestion that the molecule functions as an Fc receptor for IgM. CD7 is the most consistently expressed T cell antigen in lymphoblastic lymphomas and leukaemias, and is therefore a useful marker in identification of such neoplastic proliferations.
Fixed-embedded human tonsil
CD8
Clone: P17-V
Cat#: 10089
CD8 is a transmembrane glycoprotein co-receptor for the T cell receptor (TCR). CD8 binds to class I MHC protein. Immunohistoch emical staining of CD8 in tissue sections allow the quantitative detection of cytotoxic - suppressor T-lymphocytes.
Fixed-embedded human colon cancer
Cytokeratin 14
Clone: D19-N
Cat#: DB 099
CK14 is a member of the type I keratin family of intermediate filament proteins, it has been reported to be expressed in neoplasms of squamous cell origin.
Fixed-embedded human squamous cell carcinoma
Cytokeratin 16
Clone: R20-S
Cat#: DB 100
CK16 is a type I cytokeratin. It is paired with CK6 in a number of epithelial tissues, including nail bed, oesophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with genetic skin disorders.
Fixed-embedded human skin squamous cell carcinoma
Cytokeratin 17
Clone: V21-R
Cat#: DB 101
In normal tissues, CKl7 is expressed by basal cells of complex epithelia, e.g. basal cells of pseudo-stratified epithelium in the trachea, larynx, bronchi, myoepithelial cells in salivary glands and sweat glands. In neoplastic tissue, CKl7 is expressed by squamous cell carcinomas of the lung, cervix and oral cavity.
Fixed-embedded human breast
Cytokeratin 18
Clone: R20-H
Cat#: DB 102
CK18 is a 45 kD a protein, belongs to the family of acidic type A and exists along with CK8 in most simple ductal and glandular epithelia. This antibody does not react with squamous epithelium . It reacts with benign and malignant epithelial lesions, the major ity of adenocarcinoma s, and basal cell carcinomas.
Fixed-embedded human liver
Fixed-embedded human lung adenocarcinoma
Cytokeratin 19
Clone: E16-L
Cat#: DB 103
The smallest human cytokeratin filament protein (40 kD) has been identified as CK19 and has been reported to be expressed in a large number of epithelial cell types, including many ductal and glandular epithelia.
Fixed-embedded human liver
Cytokeratin 20
Clone: E19-I
Cat#: DB 119
CK20 has been demonstrated to be almost entirely confined to the gastro intestinal epithelium, urothelium and Merkel cells of the skin.
Fixed-embedded human Merkel cells carcinoma
Cytokeratin 7
Clone: R17-S
Cat#: DB 051
CK7 has been reported in adenocarcinomas of the lung, breast, endometrium, ovary, thyroid as well as in carcinomas of the bladder and chromophobe renal cell carcinoma. CK7 and CK20 expression have been reported to show characteristic patterns on metastatic lung and adenocarcinomas.
Fixed-embedded human pancreas adenocarcinoma
Cytokeratin 8
Clone: R15-K
Cat#: DB 098
CK8, also known as tissue polypeptide antigen (TPA), is one of the first cytokeratins expressed in the embryo and persists in adult tissues. It is a major components of all simple epithelia but not of stratified squamous epithelia.
Fixed-embedded human colon adenocarcinoma
Desmin
Clone: E18-V
Cat#: DB 148
Desmin is an intermediate filament protein of both smooth and striated muscles. E18-reacts with striated (skeletal V and cardiac) as well as smooth muscle cells. In skeletal and cardiac muscles, the staining is confined to the Z-bands giving a characteristic striated appearance. Useful in indication of tumors of myogenic origin. It reacts with leimyosarcomas, as well as, rhadbomyosarcomas (striated muscle).
Fixed-embedded human uterus leiomyoma
EBV/LMP
Clone: D24-G
Cat#: 10093
Epstein-Barr virus (EBV) is a virus of the herpes family (HHV-4), and is one of the most common viruses in humans. EBV is associated with a high proportion of cases of Hodgkin's disease, expression has also been found in nasopharyngeal carcinoma and non-lymphoblastic T-cell lymphomas.
Fixed-embedded human Hodgkin lymphoma
EGFR
Clone: A20-E
Cat#: DB 092
Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kDa with tyrosine kinase activity. Increased level of EGFR is correlated with malignant transformation of squamous cells e.g. in squamous cell carcinoma of lung, head and neck, skin, cervix and oesophagus.
Fixed-embedded human placenta
EMA (CD227, Mucin-1)
Clone: G22-L
Cat#: DB 048
EMA is expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also positive on activated and unactivated T cells and plasma cells. Over-expressed in epithelial tumors, such as breast or ovarian cancer and also in non epithelial tumor cells.
Fixed-embedded human lung adenocarcinoma
ER (Estrogen receptor)
Clone: S21-V
Cat#: DB 053
This antibody recognizes a protein of 67 kDa, which is identified as estrogen receptor (ER) and stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast cancers indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Fixed-embedded human breast cancer
IgG
Clone: I17-T
Cat#: DB 174
IgG is the main antibody isotype found in blood and extracellular fluid allowing it to control infection of body tissues by binding many kinds of pathogens. The most common feature of plasmacytomas, and certain non Hodgkin's lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Fixed-embedded chronic inflammation with plasma cell reaction